Cardiac hemodynamic assessment is another component of BioMaxLabs preclinical cardiac safety assessment. Using rat, rabbit or dog, BioMaxLab can determine the effects of drugs on cardiac hemodynamic parameters, such as heart rate, arterial blood pressure (including systolic, diastolic and mean arterial blood pressure), heart contractility (LVDP, dP/dt) and coronary flow. Three animals will be used per concentration. Final reports of the cardiac hemodynamic assessment include drug effects on the study parameters including a summary of the results, description of methods used, statement of quality standard, and any amendments or deviations included as an appendix.